Extended Data Fig. 6: Significant associations between frailty-related microbial species and clinical biomarkers.
From: Gut microbial features and circulating metabolomic signatures of frailty in older adults
Colors of the heatmap are in correspondence to the beta coefficient for frailty-related clinical biomarkers from linear regression models in MaAsLin with frailty-related species (AST-transformed relative abundance) as outcomes. The biomarkers levels were standardized into Z-scores of in before including them in the MaAsLin models. All models corrected for age, sex, BMI, smoking, drinking status, educational level, and physical activity level. The Benjamini-Hochberg method is used to calculate FDR-adjusted P values to address the multiple comparison issue. These analyses were based on 1,448 samples. All the statical tests were two-sided.
