Extended Data Fig. 1: Cell cluster annotations and cell proportion changes with age in the mammary gland (related to Fig. 1). | Nature Aging

Extended Data Fig. 1: Cell cluster annotations and cell proportion changes with age in the mammary gland (related to Fig. 1).

From: Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer

Extended Data Fig. 1

(a,b) UMAP visualization mammary gland cells captured by scRNA-seq (a) and snATAC-seq (b) split by age. (c) Expression of canonical marker genes in scRNA-seq clusters. (d-f) Feature plots for selected epithelial cell (d), immune cell (e), and stromal cell (f) markers genes for cells from scRNA-seq. Colored scale represents log normalized gene expression values. (g) Proportions of epithelial, immune, and stromal cells captured by scRNA-seq and snATAC-seq in 3 M vs. 18 M mice across individual replicates (summarized in Fig. 1d, e).

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