Extended Data Fig. 5: Onset ages of Parkinson’s disease cases that carry rare deleterious variants in GBA1 and SMPD1. | Nature Aging

Extended Data Fig. 5: Onset ages of Parkinson’s disease cases that carry rare deleterious variants in GBA1 and SMPD1.

From: Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk

Extended Data Fig. 5

(a) Carriers of GBA1 qualifying variants were diagnosed with Parkinson’s disease almost 7 years younger than non-carriers (carriers: median = 55.0 years of age, range = 29-78 years of age; non-carriers: median = 62.0 years of age, range = 22-92 years of age; t-test P = 3.32 × 10-11). (b) Carriers of SMPD1 qualifying variants had similar onset age as non-carriers (carriers: median = 60.0 years of age, range = 32-86 years of age; non-carriers: median = 62.0 years of age, range = 22-92 years of age; t-test P = 0.426). (c) Onset ages in carriers of both GBA1 and SMPD1 qualifying variants. Median, 25th-75th quartiles, whiskers of 1.5× IQR shown in boxplot. *** indicates two-sided t-test P = 3.32 ×10-11.

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