Current diagnostic approaches lack sensitivity for the early-stage tau changes that precede neurofibrillary tangles in Alzheimer’s disease. Islam, Hill, Abrahamson and colleagues identify phospho-tau Ser262 and Ser356 as potential biomarkers for early-stage tau aggregation in Alzheimer’s disease. These findings could revolutionize the early diagnosis of and therapeutic strategies for Alzheimer’s disease, which offers hope for more effective interventions.
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Acknowledgements
We thank Y. Yang for her assistance with drawing the figure. The authors were supported by the National Natural Science Foundation of China (grants 82471445 and 32170988 to R.L.), and a grant from the Startup Foundation for Introducing Talent of Lanzhou University (grant 561120215 to R.L.).
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Luo, R., Yu, JT. New biomarkers for early-stage tau pathology in Alzheimer’s disease. Nat Aging 5, 734–735 (2025). https://doi.org/10.1038/s43587-025-00854-w
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DOI: https://doi.org/10.1038/s43587-025-00854-w
