Fig. 2: Model selection and correlation with epigenetic clocks. | Nature Aging

Fig. 2: Model selection and correlation with epigenetic clocks.

From: A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors

Fig. 2

a, Spearman’s rank correlation between IC and the DNAm-based estimate of IC (DNAm IC). b, DNAm levels of the 91 CpGs in the best predictive model. Samples were sorted according to IC values; CpGs were sorted according to their correlation with IC. c, Spearman’s rank correlation between DNAm IC and chronological age. d, Spearman’s rank correlations between age acceleration and epigenetic clocks (that is, age-adjusted epigenetic age) including DNAm IC. e, Scatter plots representing the relationship between the age acceleration of DNAm IC and the epigenetic clocks Horvath, Hannum, PhenoAge and GrimAge. Spearman’s rank correlation coefficients and P values for the association are displayed in the top left corner of each panel. f, Overlap between CpGs included in the IC clock (blue circles) and epigenetic clocks (yellow circles).

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