Extended Data Fig. 3: Age-associated decline in DNAm IC estimated in external datasets of blood and saliva. | Nature Aging

Extended Data Fig. 3: Age-associated decline in DNAm IC estimated in external datasets of blood and saliva.

From: A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors

Extended Data Fig. 3

a. Evaluation of DNAm IC in saliva samples across four datasets. Correlations and p-values between chronological age and DNAm IC were calculated using the Spearman’s method. b. Age-associated decline in DNAm IC estimated from blood samples. Evaluation of DNAm IC in blood or blood-related cell-type samples across 27 datasets. c. Comparison of blood and saliva DNAm IC estimates. The scatterplot on the left compares the beta values of the 91 CpG sites used in the DNAm IC model, while the scatterplot on the right shows the resulting DNAm IC values derived from blood and saliva from the same individuals (n = 19 samples). Shaded region around the fitted regression represents the 95% confidence intervals.

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