Extended Data Fig. 5: Top biological processes enriched in transcriptional changes associated with DNAm IC domains. | Nature Aging

Extended Data Fig. 5: Top biological processes enriched in transcriptional changes associated with DNAm IC domains.

From: A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors

Extended Data Fig. 5

a. Normalized enrichment scores from a gene set enrichment analysis of the gene expression signatures associated with IC scores predicted from DNA methylation data. The heatmap includes the 5 up- and down-regulated processes associated with each IC ___domain with the lowest p-values. The color scale represents the Normalized Enrichment Scores (NES). b. Correlation between cell frequency changes and DNAm IC domains. Spearman’s correlation between DNAm IC domains scores and cell count (both adjusted by chronological age). Squared numbers indicate correlations with FDR < 0.05.

Back to article page