Fig. 3: Differential plasma lipid response with the MMKD intervention based on subgroup interactions.

A heatmap highlighting lipid associations with MMKD intervention (n = 20) stratified using an interaction term for cognitive group (a), APOE genotype (b) and sex (c). Reference denotes the unadjusted linear mixed model on lipid associations with MMKD intervention. Black diamonds, nominal p value < 0.05, black block, nominal interaction p value < 0.05. Both nominal and corrected p-values are in Supplementary Datas 3–5. APOE: Apolipoprotein E, CN: Cognitively Normal, MCI: Mild Cognitive Impairment, MMKD: Modified Mediterranean-Ketogenic Diet.