Fig. 6: Correlated changes between plasma lipid species (MMKD intervention) with Alzheimer’s disease risk factors, markers and outcomes. | Communications Medicine

Fig. 6: Correlated changes between plasma lipid species (MMKD intervention) with Alzheimer’s disease risk factors, markers and outcomes.

From: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer’s disease in humans

Fig. 6

Pearson correlation between changes in select lipid species with changes in different biochemical, cognition and CSF markers. Black diamond, p < 0.05. n = 20 for all correlations except for weight (n = 17), fasting glucose (n = 17), fasting ketones (n = 16), I&D Story recall (n = 19), phosphorylated tau (n = 19), total tau (n = 19), amyloid ratio (n = 19), neurofilament light (n = 13), neurogranin (n = 9), ache (n = 13), bche (n = 13) and their ratio (n = 13). AC: Acylcarnitine, ADAS-COG12: Alzheimer’s Disease Assessment Scale-Cognitive, CSF: Cerebrospinal Fluid, FCSRT: Free and Cued Selective Reminding Test, HbA1C: Hemoglobin A1c, HDL: High-Density Lipoprotein, I&D Story Recall: Immediate and Delayed Story Recall composite, LDL: Low-Density Lipoprotein, MMKD: Modified Mediterranean-Ketogenic Diet, TG: Triglyceride, PE: Phosphatidylethanolamine, VLDL: Very-Low-Density Lipoprotein. Exact coefficients are in Supplementary Data 7.

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