Fig. 5: Comparison of manual and computational MRD assessment of an AML follow-up sample (pt13 in LAIP29). | Communications Medicine

Fig. 5: Comparison of manual and computational MRD assessment of an AML follow-up sample (pt13 in LAIP29).

From: Computational assessment of measurable residual disease in acute myeloid leukemia using mixture models

Fig. 5

a Manual gating identified two LAIPs (CD13 + /CD15 + , CD13 + /HLA-DR-) both expressed on CD34+ blasts. Both LAIPs are co-expressed as well as independently. b Computational analysis quantifies the aberrancy of individual cells. Cells with a low log-likelihood values are less likely to be observed in regenerating bone marrow. c Final output of pipeline with predicted normal (blue) and leukemic (red) cells according to the optimal log-likelihood percentile threshold. MRD, measurable residual disease; LAIP, leukemia-associated immunophenotype; LAIP29, test cohort.

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