Fig. 3: rAAV8 administration corrects lipid accumulation in liver and spleen.
From: Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer
Quantification of cholesterol and triglycerides in (a, b) liver and (c, d) spleen at 12-weeks post-injection. mg = milligrams. Bars indicate mean ± SD (n = 3-4) and statistical significance was calculated using one-way ANOVA with Tukey’s test (*p < 0.033; **p < 0.002; ***p < 0.0001). Exact p value is indicated in Supplementary Data 1. e Histological sections: Oil red O (ORO), Haematoxylin Eosin Saffron (HES) and Sirius red (SR) staining of liver (top panel), spleen (bottom panel) at 12-weeks post-injection (scale bar: 50 µm unless differently noted).
