Fig. 6: rAAV8 administration corrects lipid accumulation in liver and spleen long-term.
From: Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer
Quantification of cholesterol and triglycerides in (a, b) liver and (c, d) spleen at indicated time points (weeks). Bars indicate mean ± SD (n = 4-10). Statistical significance was calculated using two-way ANOVA with Tukey’s test (*p < 0.033; **p < 0.002; ***p < 0.0001). Exact p value is indicated in Supplementary Data 1. e Histological sections with: Oil red O (ORO; top row), Haematoxylin Eosin Saffron (HES; middle row) and Sirius red (SR; bottom row) staining of liver (top panel), and spleen (bottom panel) at 4- and 34-weeks (scale: 50 µm).
