Extended Data Fig. 7: Performance of neonate collaterals formed 4 days post injury.
ai-ii, Coronary vasculature with (ai) and without (aii) collaterals formed in response to injury, respectively. aiii, Perfusion territories of the left (LCA), right (RCA), and septal (SpA) coronary arteries. aiv, Pressure distribution based on CFD simulation. Red arrow indicates ___location of occlusion that has been virtually restored. b, Pressures at tips near real collateral (red segment) attachment sites (green circles) after injury and non-attached tips (orange circles) in the injury region. c, Pressure at every tip and only distal tips of the SpA or RCA in non-injured hearts (n=81 all RCA tips, n=67 all SpA tips, n=22 distal RCA tips, n=16 distal SpA tips, n=1 heart). d, Fold change at the connection sites of the collateral (red segment) when it is present and removed. The circle on the left is the pressure on either the RCA or SpA branch and the square on the right is the pressure on the LCA branch. e, The difference in pressure across the two connection sites with and without the collateral (n=8 connections, n=1 heart). f,g, The bar graph of percent volume-at-risk (VaR) above 30% (f), and total flow in vessels downstream of the virtual occlusion (g) within the VaR. Error bars are mean ± st dev: ****, p≤0.0001.
