Extended Data Fig. 10: Comparison of human plaque T-/myeloid-cells and mouse plaque T-/myeloid-cells. | Nature Cardiovascular Research

Extended Data Fig. 10: Comparison of human plaque T-/myeloid-cells and mouse plaque T-/myeloid-cells.

From: Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Extended Data Fig. 10

a, tSNE plot shows the expression of T cell canonical marker genes Cd4, Cd8a, Foxp3, and Ccr7 in the human-mouse integrated dataset as colored contour lines. Gene abbreviations on top of each panel; degree of relative expression indicated in colors with red designating high and gray designating low expression; b, Percentages of CD4 Teff/mem T cells, Treg T cells, naїve T cells, and γδ T cells in human plaques vs mouse plaques. c, Percentages of DCs and granulocytes in human plaques and mouse plaques. d,e, Dotplots display the tolerance-related genes in CD4 Teff/mem T cells and DCs in human plaques and mouse plaques. Patient 1–4: human coronary plaques; patient 5–7: human carotid plaques (b-e).

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