Extended Data Fig. 6: Supplementary univariate metabolomic results.

a. Violin box plots detailing paired univariate analysis of myocardial hypoxanthine and lactate content (assessed by LC-MS) in chronically ischemic versus remote LV regions from the same heart. The results demonstrating no significant difference in the levels of these metabolites between regions. b. Violin box plots detailing paired univariate analysis of myocardial glucose content and glycolytic intermediate levels (assessed by LC-MS) in chronically ischemic and remote LV regions in the same heart. The results demonstrating no significant difference in the levels of these metabolites between regions. c. Exploratory univariate analysis of the LC-MS data in 29 patients, the results suggesting elevated succinate and taurine levels in CAD patients with ≥3 dysfunctional viable segments (that is, hypocontractile region with ≤50% transmurality of late gadolinium enhancement) compared to patients with <3 dysfunctional viable segments. The boxplots visualise the median value, in addition to hinges corresponding to the first and third quartiles, and whiskers corresponding to the largest/smallest value no further than 1.5*IQR from the hinge. Analysis was conducted using the Wilcoxon-signed-rank test. LC-MS = Liquid chromatography–mass spectrometry; LV = left ventricular.