Fig. 6: APOB lipoproteins are required for the KC inflammatory response to an HFD.
From: Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
a, Venn diagram of unique and overlapping differentially expressed liver genes after 4 weeks of HFD after tamoxifen induction in female APOE cKO (n = 3) and D374Y (n = 2 versus n = 3) mice versus respective littermate controls, as determined by bulk mRNA-seq. b, Expression of conserved genes from the week 4 HFD analysis in the liver day 10 scRNA-seq dataset. c, ELISA for secreted CD5L in plasma after 4 weeks on an HFD (APOE cKO n = 5 versus n = 5 and D374Y n = 8 versus n = 8). d, Identification of conserved transcriptional response to 4 weeks of HFD from littermate controls only of both strains. e, Heat map for expression of conserved genes from APOE cKO and D374Y mice compared to littermate controls alone in response to 4 weeks of HFD. All plots are ±s.e.m. Two-sided t-test (c).
