Fig. 7: CD8 T cells maintain KC responses to atherogenic dyslipidemia.
From: Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
a, Venn diagram representing overlapping genes among differentially regulated genes common to dyslipidemic female APOE cKO and D374Y mice after 4 weeks of HFD, differentially regulated genes in dyslipidemic APOE cKO mice after 4 weeks of HFD and treated with anti-CD8 antibody relative to PBS-treated mice and D374Y mice after 4 weeks of HFD and treated with anti-CD8 antibody relative to PBS-treated mice, as determined by mRNA-seq. b, Transcript per million (TPM) of selected KC-specific genes showing downregulation after 4 weeks on an HFD and treatment with anti-CD8 antibody (APOE cKO n = 3 versus n = 3 versus n = 2 and D374Y n = 2 versus n = 3 versus n = 3). All plots are mean ± s.e.m. c, Plasma lipoprotein fractionation profiles (µmol L−1). All curves were calculated as an average of plasma pooled from female mice (n = 5–6). DE, differentially expressed; VLDL, very-low-density lipoprotein.
