Extended Data Fig. 3: Palantir analysis of Control and macHif1aKO mice 5 days after MI. | Nature Cardiovascular Research

Extended Data Fig. 3: Palantir analysis of Control and macHif1aKO mice 5 days after MI.

From: Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury

Extended Data Fig. 3

a, PCA plot of cell cycle genes in Control and macHif1aKO scSEQ data 5 days after I/R before (Cell Cycle PCA) and after (Post Correction) regressing out cell cycle scores. b, Reference UMAP of Control and macHif1aKO scSEQ data 5 days after I/R highlighting the starting cell used. Starting cell was determined by selecting the Control monocyte with the highest monocyte Z-score (Plac8, Ly6c2). c, Force directed layout (FDL) output of Palantir analysis highlighting each cell subpopulation in Control and macHif1aKO scSEQ data. d, Terminal state probability scores from Palantir analysis indicating the likelihood that a cell becomes either Trem2 or cDC2.

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