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Atherosclerosis

Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond

Nature Cardiovascular Research volume 4, pages 8–10 (2025)Cite this article

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Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.

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Fig. 1: Single-cell anatomy of atherosclerotic vascular plaque.

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Acknowledgements

This work was supported by NIH grants R01HL171045 (T.Q.), R01HL134817 (T.Q.), R01HL139478 (T.Q.), R01HL156846 (T.Q.), R01HL151535 (T.Q.), R01HL158525 (T.Q.), UM1 HG011972 (T.Q.), U01HG011762 (T.Q.) and K08HL153798 (P.C.), and American Heart Association grants 23SCISA1144703 (P.C.), 24SCEFIA1248386 (P.C.) and 695 20CDA35310303 (P.C.).

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  1. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Paul Cheng & Thomas Quertermous

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  1. Paul Cheng
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  2. Thomas Quertermous
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Correspondence to Thomas Quertermous.

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The authors declare no competing interests.

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Cheng, P., Quertermous, T. Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond. Nat Cardiovasc Res 4, 8–10 (2025). https://doi.org/10.1038/s44161-024-00568-z

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