Extended Data Fig. 1: Loss of hand1 in zebrafish.
From: PDGFRA is a conserved HAND2 effector during early cardiac development
a, Phylogenetic profile of HAND1 on a species level resolution. Colour code indicates the feature architecture similarity (FAS) score of the orthologues to the human seed protein. Dot colour (FAS_F) and cell colour (FAS_B) represent the feature architecture similarity score between two orthologs using the human protein (dot colour) and the ortholog (cell colour) as reference, respectively. b, PhyloView representation of HAND1 and HAND2 in the human genome and their ortholog in other genomes. HAND1/HAND2 and their orthologs are positioned in the center, aligned with their neighboring genes, in various genomes. Genes of the same color represent orthologs.
