Fig. 9: Examples of BRAID surfaces not fit well to the NCI-ALMANAC dataset. | npj Drug Discovery

Fig. 9: Examples of BRAID surfaces not fit well to the NCI-ALMANAC dataset.

From: Predicting drug combination response surfaces

Fig. 9

On top: cell line HL-60(TB), drugs pentostatin (id 218321) and streptozotocin (id 85998). Middle: cell line NCI-H226, drugs nilotinib (id 747599) and floxuridine (id 27640). Bottom: cell line OVCAR-8, drugs capecitabine (id 712807) and bendamustine (id 138783). The two first plots in each row show the NCI-60 monotherapy responses in black, with blue crosses highlighting the NCI-ALMANAC monotherapy response values, while the curve displays the responses from the Hill equation from the BRAID model. Third column displays the full combo data matrix, and the final column shows the fitted BRAID surface.

Back to article page