Figure 3 | Scientific Reports

Figure 3

From: The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys

Figure 3

Extinction of tDCS accumulated treatment effects and contributions of different brain areas to tDCS effects for PD treatment.

(a) After six months’ recovery, monkey 3# and 4# were administered with additional MPTP to restore the Kurlan scale scores same to the scores in Fig. 2(a). (b) Extinction of tDCS accumulated treatment effects on M1 after six months’ recovery. There was no significant difference between the effects of the first tDCS and the last tDCS in each monkey (Multi-factor ANOVA: P = 0.881). (c) The effects of tDCS treatment (0.2 mA, 5 min) on different brain areas. The PD scores only decreased after tDCS on M1. Sham: control of anodal tDCS on M1 with no stimulation; PFC: prefrontal cortex; LT: left temporal lobe; RT: right temporal lobe; M1: primary motor cortex. Multi-factor ANOVA: The interaction of region × tDCS was significant, **P < 0.01. Values in (b,c) represent mean ± STD.

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