Figure 4 | Scientific Reports

Figure 4

From: Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development

Figure 4

Effects of sirt6 overexpression on MMP-13 and collagen-II production in IL-1β induced chondrocytes.

(A) Chondrocytes degeneration was induced after IL-1β treatment (10 ng/ml) for 0, 1, 3 and 5 days. The western blotting analysis revealed an increase in level of MMP-13 and a decrease in the level of sirt6 in a time-dependent manner. (B) MMP-13 level up-regulation after IL-1β treatment for 24 h was inhibited by the overexpression of sirt6. Meanwhile, colleagn II level was significantly decreased after IL-1β treatment and this effect was also significantly attenuated by sirt6 overexpression.

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