Figure 7
Expression of miR-181b in NSCLC tissues is negatively correlated with TGFβR1 expression and responses of NSCLC patients to DDP-based chemotherapy.
(a) qRT-PCR detection of relative miR-181b expression in sensitive group (n= 20) and insensitive group (n= 18) NSCLC tissues. Abundance of miR-181b was normalized to U6 RNA. (b) qRT-PCR detection of relative TGFβR1 mRNA expression in sensitive group (n= 20) and insensitive group (n= 18) NSCLC tissues. Abundance of TGFβR1 was normalized to GAPDH. (c) Immunostaining of TGFβR1 protein expression in sensitive and insensitive NSCLC tissues. (d) The OS curves for the high-miR-181b expression group (n= 21) and the low-miR-181b expression group (n= 17). (e) The DFS curves for the high-miR-181b expression group (n= 21) and the low-miR-181b expression group (n= 17). (f) A statistically significant inverse correlation between miR-181b and TGFβR1 mRNA levels in 38 cases of NSCLC tissues.
