Figure 4
From: The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat
Morphological examination of liver, kidney and testis revealed the phenotypes of hepatic steatosis, nephropathy and infertility in Lep∆I14/∆I14 rats.
(A) Lep∆I14/∆I14 rats have many hepatocyte vacuoles in liver, a typical phenomenon of non-alcoholic fatty liver disease (NAFLD). The phenotype is progressed from week 8. (B) The kidney of Lep∆I14/∆I14 rats shows glomeruli hypertrophy, dilation of tubules and many protein casts within tubules. The phenotype was observed at week 16. (C) The testis of Lep∆I14/∆I14 rats has hollow seminiferous tubules losing many germ cells in the intermediate and adluminal layers, which is more severe at week 16. Sections were stained with HE and photographed at 100× magnification.
