Figure 4 | Scientific Reports

Figure 4

From: Repetitive Electroacupuncture Attenuates Cold-Induced Hypertension through Enkephalin in the Rostral Ventral Lateral Medulla

Figure 4

Involvement of rVLM δ-opioid receptors in EA modulation of blood pressure (BP) in rats with cold-induced hypertension (CIH).

Panels A,B: δ-opioid receptor blockade in the rVLM reversed EA’s action in lowering BP in CIH rats. Panels C,D: decrease in BP after activation of δ-opioid receptors in the rVLM of CIH rats treated with sham-EA. Panels A,C show original BP tracings before and after bilateral microinjection of a δ-opioid receptor antagonist (ICI 174,864; 1 mM in 50 nl) and agonist (DADLE; 10 nM in 50 nl) into the rVLM. Arrows in Panels A,C indicate sequential bilateral microinjections into the rVLM. In Panels B,D, *indicates significant differences compared to before microinjection, *P < 0.05; **P < 0.01.

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