Figure 4: Silencing of DHCR24 suppresses EC cell invasion and migration. | Scientific Reports

Figure 4: Silencing of DHCR24 suppresses EC cell invasion and migration.

From: Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma

Figure 4

(A) qRT-PCR analysis of the DHCR24 expression after DHCR24 siRNA interference. (B) Successful DHCR24 silencing was confirmed by immunoblotting. (C) The level of migration was probed in the DHCR24-silenced group and the DHCR24 control group derived from KLE and HEC-1B cells. (D) The level of invasion was assessed in the DHCR24-silenced group and the DHCR24 control group derived from KLE and HEC-1B cells. (E) The level of migration ability of HEC-1B cells treated with insulin, GSK1904529A, and the silencing of DHCR24 was determined using a transwell assay. (F) The invasion ability of HEC-1B cells treated with insulin, GSK1904529A, and silencing of DHCR24 was probed. The data are presented as the mean ± SD of three independent experiments. (*p < 0.05; **p < 0.01; ***p < 0.001).

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