Figure 1
From: Brain-derived neurotrophic factor increase during treatment in severe mental illness inpatients
The mean BDNF serum levels in (a) SMI patient total sample in admission and upon discharge and in healthy controls and (b) in SMI patients subdivided by diagnosis in admission and upon discharge. (a) In admission time point, SMI patients’ BDNF serum level has a large difference when compared with controls (ES: −0.80; 95% CI: −1.05, −0.56). It increases during the inpatient treatment and remains moderately reduced at discharge when compared with controls (ES: −0.55; 95% CI: −0.81, −0.29). (b) BDNF levels among diagnoses are similar in both moments of the treatment. BDNF, brain-derived neurotrophic factor; Bd, bipolar depression; CI, confidence interval; ES, effect size; Ma, mania; Md, major depression; SMI, severe mental illness; Sz, schizophrenia.
