Volume 34 Issue 9, September 2024

The image depicts the Chinese legend "The Magic Brush" ("Shen Bi Ma Liang"). The towering mountain symbolizes the rugged protein fitness landscape, with reaching the summit representing the challenging tasks in protein engineering. Our proposed method, ProMEP, serves as the magic brush, sketching out a rapid path to the peak for biologists. The brush’s handle, adorned with dots, lines, and jewels, signifies the power of artificial intelligence technology driving this journey. See page 630–647 by Peng Cheng et al. for details.