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  • Series |

    A series of short articles that provides a platform for Young Investigators/Early Career Researchers to share their experiences and thoughts on their careers, and to offer advice on how to navigate in a challenging and rapidly-evolving research environment. Come back to this page as we add more content!

    Image: Vicky Summersby

  • Focus |

    This focus features Reviews and selected short articles that discuss the mechanisms and functions of phase separation, examining the roles of RNA and the properties and disease-relevance of the nucleolus and protein condensates. We also include a Roadmap to study and elucidate the cellular roles of condensates, and a selection of recent primary research articles from the Nature journals.

    Image: Vicky Summersby

  • Focus |

    Mitochondria are the powerhouses of cells, and their function is often compromised in disease and ageing. This focus issue brings together Reviews and Comments that discuss several aspects of mitochondrial function and the cellular mechanisms that are in place to maintain a functional mitochondrial network. They also discuss the bases of mitochondrial diseases and strategies to prevent their transmission to offspring.

    Image: Vicky Summersby

  • Collection |

    This collection of primary research articles, reviews and protocols focuses on an emerging topic of mechanobiology, highlighting the broad involvement of mechanical forces in different biological contexts, their roles in development, physiology and disease, and how these forces are sensed and transduced to produce biologically-relevant responses. The collection also showcases new technical approaches to modulate mechanobiology, which in the future could be used to control cell fate and behaviour for therapeutic benefits.

    Image: Vicky Summersby

  • Collection |

    The 2020 Nobel Prize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer Doudna for their pioneering work in gene-editing.

    Image: Springer Nature/The Nobel Foundation/Imagesource

  • Collection |

    NRMCB is 20! To mark this anniversary, we selected Review articles in 10 core areas of the journal. The Reviews are presented in pairs, an older and a more recent one, alongside 10 commissioned Journal Clubs — together the articles showcase developments and key discoveries in each research field.

  • Milestone |

    The discovery of antisense RNA phenomena has profoundly altered our understanding of gene regulation and revolutionized the way biological research is conducted.

  • Focus |

    DNA, RNA and proteins are dynamically modified by methylation to regulate gene expression and protein function. Methylation dysregulation is associated with cancer and other diseases. The Reviews in this focus issue showcase the latest understanding of the mechanisms and roles of methylation in animals and of its clinical relevance.

    Image: Vicky Summersby

  • Collection |

    This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease.

    Image: V. Summersby

  • Series |

    In this article series, Nature Reviews Molecular Cell Biology looks at the progress that has been made in our molecular understanding of different modes of cell death and of autophagy as both a survival and death mechanism.

    Image: Vicky Summersby