Abstract
THE alkaloids colchicine and vinblastine interfere with the assembly of microtubules, yet they also affect several properties of the surface membrane of animal cells. They disorganise an apparent topographical separation between surface areas involved in membrane transport and in phagocytosis in rabbit polymorphonuclear leukocytes1, inhibit the agglutination of these cells by concanavalin A (ref. 2) and inhibit the concanavalin A-dependent adherence of red blood cells to transformed 3T3 fibroblasts3.
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WADDELL, A., ROBSON, R. & EDWARDS, J. Colchicine and Vinblastine Inhibit Fibroblast Aggregation. Nature 248, 239–241 (1974). https://doi.org/10.1038/248239a0
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DOI: https://doi.org/10.1038/248239a0
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