Figure 1 | Laboratory Investigation

Figure 1

From: Fibrinolytic Balance of the Arterial Wall: Pulmonary Artery Displays Increased Fibrinolytic Potential Compared with Aorta

Figure 1

Localization of tissue plasminogen activator (t-PA) mRNA by in situ hybridization analysis of pulmonary artery (Pa) and aorta (Ao) from the same individual. Purple immunoreactivity indicates positive hybridization signal. Sections have been counterstained with hematoxylin. A, t-PA expression in the Pa medial layer and within the adventitia in the muscular layer of the vasa vasorum, and for comparison, in the corresponding ascending Ao (e to h, arrowheads point to vasa vasorum; all × 40 magnification). b and f, Parallel sections hybridized with the sense control riboprobe. c, t-PA in situ hybridization signal localized within Pa endothelial cells (PaECs; arrow in a); g, a corresponding experiment demonstrating signal within aortic endothelial cells (AoECs; arrow in e). Control experiments using sense probes are shown in d and h (× 1000 magnification, oil immersion). Scale bars, 10 μm.

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