Table 1 Growth inhibitory effect of C1A compared with SAHA in a panel of cancer cell lines (mean±s.d.)
From: A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth
Cell type | Cell line | C1A ( μ M) | SAHA ( μ M) |
|---|---|---|---|
Breast | MCF7 | 3.3±0.15 | 3.5±0.6 |
|  | MDA-MB-435 | 7.7±0.2 | 0.96±0.05 |
|  | T47D | 4.5±0.03 | 1.2±0.2 |
Colon | HCT-116 | 3.3±1.6 | 0.48±0.1 |
Endometrial | Ishikawa | 5.6±0.03 | 0.67±0.05 |
Epidermal | A431 | 4.1±0.6 | 1.1±0.1 |
Lung | A549 | 5.8±2 | 1.8±0.6 |
Myeloma | ARH-77 | 3±0.55 | 0.48±0.24 |
|  | KMS-11 | 0.48±0.24 | 0.27±0.03 |
Neuroblastoma | SH-SY5Y | 0.28±0.01 | 0.92±0.3 |
|  | Kelly | 0.18±0.01 | 0.4±0.12 |
|  | S-K-NAS | 3.3±1.5 | 0.49±0.02 |
|  | BE2C | 0.66±0.19 | 0.63±0.08 |
Ovarian | A2780 | 0.96±0.44 | 0.82±0.1 |
|  | IGROV1 | 1.1±0.2 | 1.2±0.2 |
Prostate | LNCAP | 3.7±1.5 | 1.7±1.2 |
|  | DU-145 | 4.6±0.6 | 0.54±0.01 |
