Figure 4 | British Journal of Cancer

Figure 4

From: Global metabolomic profiling of uterine leiomyomas

Figure 4

Schematic of the highlighted metabolic alterations in leiomyomas of the FH and MED12 subtypes. All leiomyomas displayed reduced homocarnosine and haeme metabolite levels and subtype-specific alterations in lipids. (A) FH-deficient leiomyomas displayed dysregulation of TCA cycle, PPP, and the metabolism of amino acids and nucleotides. (B) MED12-mutated leiomyomas harboured alterations affecting retinol, ascorbate, amino acids, and dipeptides. ADSL=adenylosuccinate lyase; ASL=argininosuccinate lyase; BCAA=branched chain amino acid; BCKDC=branched-chain alpha-keto acid dehydrogenase complex; FH=fumarate hydratase; HMOX1=haeme oxygenase 1; MED12=mediator complex subunit 12; NRF2=nuclear factor (erythroid-derived 2)-like 2; PPP=pentose phosphate pathway; S-ado=N6-succinyladenosine; SAM=S-adenosylmethionine; TCA=tricaboxylic acid.

Back to article page