Table 1 Proteins associated with saP21 identified by MS following ChIbRP§

From: saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

Accession#

Gene Symbol

Protein Name

saP21- Bio(S)*

saP21- Bio(AS)*

Unique to Bio(AS)

dsRNA binding

O95793

STAU1

dsRNA-binding protein Staufen homolog 1

2

4

 

Q12906

ILF3

Interleukin enhancer-binding factor 3

4

18

 

Q5TA56

EIF2C3

Eukaryotic translation initiation factor 2C, 3

 

2

Yes

Q9UKV8

EIF2C2

Protein argonaute-2

18

44

 

Nucleic acids binding/ Splicing/ Chromatin/ Transcription

P11940

PABPC1

Polyadenylate-binding protein 1

2

5

 

P22626

HNRNPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1

 

2

Yes

P31943

HNRNPH1

Heterogeneous nuclear ribonucleoprotein H

 

1

Yes

P52272

HNRNPM

Heterogeneous nuclear ribonucleoprotein M

 

2

Yes

Q15366

PCBP2

Poly(rC)-binding protein 2

 

2

Yes

P23246

SFPQ

Splicing factor, proline- and glutamine-rich

 

1

Yes

Q6PD62

CTR9

RNA polymerase-associated protein CTR9 homolog

 

1

Yes

Q08211

RHA

ATP-dependent RNA helicase A

 

2

Yes

P04908

HIST1H2AB/E

Histone H2A type 1-B/E

 

1

Yes

P0CG47

UBB

Polyubiquitin-B

 

1

Yes

P06748

NPM1

Nucleophosmin

2

6

 

Translation

P60842

EIF4A1

Eukaryotic initiation factor 4A-I

 

1

Yes

P68104

EEF1A1

Elongation factor 1-alpha 1

3

2

 

Metabolic proteins

O00763

ACACB

Acetyl-CoA carboxylase 2

 

1

Yes

P06733

ENO1

Alpha-enolase

 

1

Yes

Q13085

ACACA

Acetyl-CoA carboxylase 1

2

14

 

P04075

ALDOA

Fructose-bisphosphate aldolase A

 

5

Yes

P14618

PKM

Pyruvate kinase isozymes M1/M2

2

8

 

P00558

PGK1

Phosphoglycerate kinase 1

 

4

Yes

Chaperones

P07900

HSP90AA1

Heat shock protein HSP 90-alpha

 

5

Yes

P08107

HSPA1A/B

Heat shock 70 kDa protein 1A/1B

 

1

Yes

P11142

HSPA8

Heat shock cognate 71 kDa protein

6

9

 

Cytoskeleton proteins

A6NMY6

ANXA2P2

Putative annexin A2-like protein

 

2

Yes

P07355

ANXA2

Annexin A2

1

4

 

P04350

TUBB4A

Tubulin beta-4 chain

 

1

Yes

P07437

TUBB

Tubulin beta chain

 

2

3

P18206

VCL

Vinculin

 

1

Yes

P60709

ACTB

Actin, cytoplasmic 1

12

17

 

Q15149

PLEC

Plectin

 

7

Yes

Q5D862

FLG2

Filaggrin-2

 

2

Yes

P21333

FLNA

Filamin-A

 

1

Yes

P68363

TUBA1B

Tubulin alpha-1B chain

2

4

 

Ribosomal proteins

P08865

RPSA

40S ribosomal protein SA

2

4

 

P15880

RPS2

40S ribosomal protein S2

 

1

Yes

P18124

RPL7

60S ribosomal protein L7

 

1

Yes

Miscellaneous

P01833

PIGR

Polymeric immunoglobulin receptor

 

2

Yes

Q8IVZ3

OSBPL1A

OSBPL1A protein

1

1

 

P02808

STATH

Statherin

 

1

Yes

Total non-redundant proteins

  

15

42

 
  1. §For detailed listing of proteins recovered by MS, see Supplementary information, Table S2.
  2. *Number of peptides for each unique protein associated with either saP21-Bio(S) or saP21-Bio(AS).
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