Extended Data Figure 3: Removal of miR-142-3p binding sites in the 3′NTR of EEEV does not alter replication in BHK-21 fibroblasts. | Nature

Extended Data Figure 3: Removal of miR-142-3p binding sites in the 3′NTR of EEEV does not alter replication in BHK-21 fibroblasts.

From: RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

Extended Data Figure 3

a, Red boxes indicate the four miR-142-3p binding sites in the 3′ NTR. Numbers represent nucleotide (nt) positions at the start and end of each miRNA binding site. b, Grey boxes correspond to the complimentary nts in the EEEV 3′ NTR and miR-142-3p. c, EEEV mutant 11337 contains a deletion in the 3′ NTR from nt 11,337 to 11,596. d, Replication of wild-type EEEV and 11337 in BHK-21 cells. n = 3 independent experiments. Error bars indicate geometric mean ± s.d., and asterisks indicate differences that are statistically significant (**P < 0.01).

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