Extended Data Figure 4: miR-142-3p binding sites in EEEV restrict replication in human macrophage/monocyte cell lines and primary murine Ifnar1−/− BMDCs.
From: RNA viruses can hijack vertebrate microRNAs to suppress innate immunity
a, b, Replication of wild-type EEEV and 11337 in human K562 (a) and THP-1 (b) cells. n = 2 (THP-1) and 3 (K562) independent experiments. c, Removal of type I IFN does not alleviate wild-type EEEV restriction in primary murine Ifnar1−/− BMDCs. n = three independent experiments. Data represent the geometric mean ± s.d., and asterisks indicate differences that are statistically significant (*P < 0.05, **P < 0.01, ***P < 0.001).
