Extended Data Figure 7: Functional analysis of saccharin-modulated microbiota.
From: Artificial sweeteners induce glucose intolerance by altering the gut microbiota
a, b, Changes in bacterial relative abundance occur throughout the bacterial genome. Shown are changes in sequencing coverage along 10,000 bp genomic regions of Bacteroides vulgatus (a) and Akkermansia muciniphila (b), with bins ordered by abundance in week 0 of saccharin-treated mice. c, Fold change in relative abundance of modules belonging to phosphotransferase systems (PTS) between week 11 and week 0 in mice drinking commercial saccharin, glucose or water. Module diagram source: KEGG database. d, Enriched KEGG pathways (fold change > 1.38 as cutoff) in mice consuming HFD and pure saccharin versus water compared to the fold change in relative abundance of the same pathways in mice consuming commercial saccharin (week 11/week 0).
