Extended Data Figure 8: CAF-1 suppression facilitates Sox2 binding to chromatin.
From: The histone chaperone CAF-1 safeguards somatic cell identity
a, Sox2 ChIP-seq enrichment across pluripotency-specific super-enhancer elements at day 3 of reprogramming in the presence of indicated shRNA vectors. b, Venn diagram depicting shared and unique Sox2 targets in Chaf1a and Renilla knockdown cells. c, Bar graph shows the number and fraction of ES-cell-specific Sox2 targets (blue colour) among Sox2-bound sites that are unique to Chaf1a or Renilla knockdown cells at day 3 of OKSM expression. d, Sox2 ChIP-seq analysis of Chaf1a and control shRNA-infected cells at day 3 of reprogramming to determine enrichment of Sox2 binding across lineage-specific super-enhancer elements43 (C2C12, myoblast cell line; proB, progenitor B cells; Th, T helper cells; P value <10−15 for all comparisons between Chaf1a knockdown cells and control).
