Extended Data Figure 3: polg-1, hmg-5 and drp-1 mRNAs are induced in atfs-1(et18) worms, and mitochondrial fusion is required for the development of atfs-1(et18) worms harbouring ∆mtDNA. | Nature

Extended Data Figure 3: polg-1, hmg-5 and drp-1 mRNAs are induced in atfs-1(et18) worms, and mitochondrial fusion is required for the development of atfs-1(et18) worms harbouring ∆mtDNA.

From: Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

Extended Data Figure 3

a, polg-1, hmg-5 and drp-1 transcripts as determined by qRT–PCR in wild-type and atfs-1(et18) worms. n = 3; error bars, mean ± s.d.; *P < 0.03 (Student’s t-test). RFU, random fluorescent units. b, Images of synchronized ∆mtDNA, atfs-1(et18), and atfs-1(et18);∆mtDNA worms raised on control or fzo-1 RNAi. Scale bar, 1 mm. c, ∆mtDNA quantification as determined by qPCR in ∆mtDNA worms raised on control or hmg-5 RNAi. n = 3; error bars, mean ± s.d.; *P < 0.03 (Student’s t-test).

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