Extended Data Figure 1: Standard IMPC allele variants included in this study.
From: High-throughput discovery of novel developmental phenotypes
a, Conditional-ready, knockout-first allele (tm1a) design (top) with LacZ reporter, and the Cre-converted (tm1b, bottom) version lacking the neo cassette and critical exon. The promoter driven variant is illustrated. b, Schematic of the small number of alleles included where the distal loxP had been lost during targeting (tm1e, top) and the converted (tme.1) variant with the neo cassette removed. c, Velocigene ‘definitive null’ design (top, tm1) where the LacZ cassette replaces the coding sequence of the target gene, and Cre-excised variant (bottom, tm1.1). Details of all alleles used are listed in Supplementary Table 2 and 5. Additional details and schematics of all allele variants are available at http://www.mousephenotype.org/about-ikmc/targeting-strategies.
