Extended Data Figure 2: Distribution of lethal, subviable and viable lines for each IMPC Centre.
From: High-throughput discovery of novel developmental phenotypes
Spine (a) and mosaic (b) plots of progress examining primary viability of IMPC lines for each IMPC Centre, segmented by ‘Lethal’, ‘Subviable’ or ‘Viable’ outcome. The mosaic plot shows the significant overrepresentation of viable lines from UCD and lethal lines from ICS, NING, and TCP. c, d, Spine and mosaic plots of primary viability outcome by chromosome, showing no significant deviation from the expected distribution. e, Comparison of the percentage of viable, subviable, and lethal lines between genes for which no targeted knockout alleles have been reported (novel) and genes for which one or more knockout alleles has been reported. BCM, Baylor College of Medicine; GMC, German Mouse Clinic; H, MRC Harwell; ICS, Institut Clinique del la Souris (PHENOMIN); J, The Jackson Laboratory; NING, Model Animal Research Center, Nanjing University; RBRC, RIKEN BioResource Center; TCP, Toronto Centre for Phenogenomics; UCD, University of California, Davis; WTSI, Wellcome Trust Sanger Institute.
