Abstract
An ilv A gene (specifying threonine deaminase) mutation causes an Escherichia coli K12 strain to be leucine sensitive. The regulation of all the isoleucine and valine biosynthetic enzymes and of the branched chain aminoacyl-tRNA synthetases is affected in this mutant. We postulate that threonine deaminase is a positive effector in the multivalent control process.
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LEVINTHAL, M., WILLIAMS, L., LEVINTHAL, M. et al. Role of Threonine Deaminase in the Regulation of Isoleucine and Valine Biosynthesis. Nature New Biology 246, 65–68 (1973). https://doi.org/10.1038/newbio246065a0
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DOI: https://doi.org/10.1038/newbio246065a0
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