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Motor learning with oligodendrocytes

Nature Reviews Neuroscience volume 17, page 604 (2016)Cite this article

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Oligodendrocyte precursor cells (OPCs) are produced throughout life and are required for motor learning, but their role in this process is unclear. Within 2–3 hours of beginning a motor-learning task, mice lacking the transcription factor MYRF (myelin regulator factor) showed reduced levels of new oligodendrocytes and impaired learning. Wild-type mice trained in this task exhibited accelerated differentiation of OPCs, suggesting that OPC differentiation contributes to motor learning in this task.

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References

  1. Xiao, L. et al. Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nat. Neurosci. http://dx.doi.org/10.1038/nn.4351 (2016)

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  1. Sian Lewis
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Lewis, S. Motor learning with oligodendrocytes. Nat Rev Neurosci 17, 604 (2016). https://doi.org/10.1038/nrn.2016.122

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