Fig. 4 | Journal of Human Genetics

Fig. 4

From: Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

Fig. 4

Causal estimates of a 1 SD increase in morning plasma cortisol on relevant disease and trait outcomes. Estimates are from two-sample Mendelian randomisation analyses using inverse variance weighting to combine estimates from each genetic variant. a Outcomes from UK Biobank (chronic ischaemic heart disease, cases = 8755, controls = 328,444; myocardial infarction, cases = 7790, controls = 328,893; diabetes mellitus, cases = 16,183, controls = 320,290; body mass index, sample size = 336,107; osteoporosis, cases = 5266, controls = 331,893); (b) Equivalent outcomes from non-UK Biobank sources—CARDIoGRAMplusC4D (coronary heart disease, cases = 60,801, controls = 123,504; myocardial infarction, cases = 43,676, controls = 128,199), DIAGRAM (type 2 diabetes, cases = 26,488, controls = 83,964), GIANT (BMI, sample size = 339,224) and GEFOS (lumber spine mineral density, sample size = 28,498)

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