Fig. 7: Knockdown of derlin-1 significantly reversed the E2-induced decrease in α-ENaC. | Experimental & Molecular Medicine

Fig. 7: Knockdown of derlin-1 significantly reversed the E2-induced decrease in α-ENaC.

From: Estrogen negatively regulates the renal epithelial sodium channel (ENaC) by promoting Derlin-1 expression and AMPK activation

Fig. 7

a Downregulation of derlin-1 by shRNA-derlin-1 transfection in mpkCCDc14 cells significantly reversed the E2-induced decrease in α-ENaC. b Quantification of the α-ENaC expression shown in (a) normalized to β-actin expression. c Quantification of the derlin-1 expression shown in (a) normalized to β-actin expression. The bars are the means ± SE values from three independent experiments. *P < 0.05

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