Fig. 2: The establishment of a diabetic rat model and the expression level of inflammatory and degradation factors in synovial tissue. | Experimental & Molecular Medicine

Fig. 2: The establishment of a diabetic rat model and the expression level of inflammatory and degradation factors in synovial tissue.

From: Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis

Fig. 2

a Animal model establishment method. b The blood glucose levels of rats in the different groups. c The weight changes of rats in the different groups after injection of STZ at 1 week and 5 to 10 weeks. d India ink staining of the articular cartilage of the femoral condyle in rats in the different groups. e–g Safranin O staining (e) of tibial plateau cartilage of rats in the different groups, scale bar: 100 μm. h, i: H&E staining (h) and synovitis score (i) of the knee joint synovium of rats in the control and DM groups, scale bar: 25 μm. j, k Representative IHC images and the IOD values of inflammatory and degradation factors in synovial tissue in the control and DM groups; scale bar: 50 μm. Ten fields of view for each sample were selected for analysis. The values are the means±S.E.M., n = 10. The Mann–Whitney U test was used for statistical analysis. *P < 0.05, **P < 0.01 vs. the control.

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