Fig. 1: piRNA expression profiles in RCC and characterization of piR-1742. | Experimental & Molecular Medicine

Fig. 1: piRNA expression profiles in RCC and characterization of piR-1742.

From: piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination

Fig. 1

a Heatmap showing differentially expressed piRNAs. b Symmetric scatter plot showing differentially expressed piRNAs between RCC and normal samples. c Volcano plot showing differential expression of piRNAs between RCC and normal samples. d The expression levels and chromosomal locations of the top 15 upregulated piRNAs and downregulated piRNAs. e piR1742 expression levels in RCC tumors and corresponding normal samples in TCGA. The expression of piR1742 in tumors of different grades and stages: tumor grade (f), tumor stage (g) and clinical T stage (h). i Kaplan‒Meier analysis of RCC patients with low versus high expression levels of piR-1742. j GSEA of piR-1742. k-l Representative images of piR-1742 ISH and IHC of MUC12 and percentages of piR-1742 and MUC12 expression in tissues in RCC patients, Scale bar: 50 μm. m Correlation of piR-1742 and MUC12 expression based on the H-score. *p < 0.05, **p < 0.01, ***p < 0.01.

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