Fig. 2: Mutational Signatures in TNAC and LK-TNBC.

A The proportions of COSMIC mutational signatures (version 2) inferred by deconstructSigs analysis of TNAC and LK-TNBC samples. The top bar plot indicates the TMB of each sample, and a red dotted horizontal line represents the cutoff (10 mutations/Mb) for hypermutation. TNAC and LK-TNBC samples were sorted by TMB. The bottom heatmap represents somatic point mutations in the DNA mismatch repair (MMR)-associated genes. B The mutational signatures showing significant differences between TNAC and LK-TNBC (top) and between hypermutated and nonhypermutated samples in TNAC (bottom) (p < 0.05). P values were calculated by Student’s t test. The lower and upper limits of the boxes indicate the 25th and 75th percentiles, respectively, and the horizontal bold line within each box represents the median. Outliers are separately plotted as circles.