Fig. 3: Intramural thrombosis and neovascularization in aortic aneurysm.
From: Aortic aneurysms: current pathogenesis and therapeutic targets
Thrombus-mediated deprivation of oxygen and nutrients in the aortic wall stimulates neovascularization from the vasa vasorum in the aneurysm wall, inducing the recruitment of inflammatory cells that produce inflammatory mediators and leading to the weakening of the aneurysm wall and aneurysm rupture. RBC red blood cell, MMPs matrix metalloproteinases, ECM extracellular matrix.
